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Abstract #4110

Motion-correction algorithm for free-breathing, fast-heart rate small animal studies on clinical scanners

Matthew Tarasek1, Jeannette Roberts2, Deirdre Cassidy 3, Thomas Foo1, Desmond Yeo1, Randall Carter2, and Brian Bales2

1MRI, GE Global Research, Niskayuna, NY, United States, 2Life Sciences, GE Global Research, Niskayuna, NY, United States, 3Life Sciences, GE Healthcare UK, United Kingdom, United Kingdom

Small animal scanning methods are common for preclinical efficacy evaluation of contrast agents, and naïve animal studies done on clinical scanners are becoming more prevalent. Unfortunately, scanning small animals on large-bore clinical scanners creates several challenges such as motion effects due to organ movement and very fast heart-rates. Here we provide a retrospective motion-correction algorithm for fast-heart-rate/free-breathing small animals based on diaphragm tracking. Results show a ten-fold reduction in baseline contrast region signal uncertainty and significant accuracy improvement of pharmacokinetic time-constant estimation.

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