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Abstract #4174

Platform for investigating spatial and intensity parameters for phase-sensitive MRI focal localization with steerable single element focused ultrasound transducers through skull

Spencer Brinker1, Frank Preiswerk1, and Nathan McDannold1

1Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States

A platform is designed and constructed for investigating Focused Ultrasound (FUS) spatial and intensity focal parameters during phase-sensitive MRI focal localization. Recently, there has been a large interest to use single element transducers to deliver therapy to the brain. Spatial accuracy and intensity safety limits need further investigation. The platform developed in this project uses 3D Slicer software to incorporate MRI and neuronavigation camera coordinates for guiding an automated 3D hydrophone mapping system. A 272 kHz single element FUS transducer, ex vivo skull, and gel phantom are used to demonstrate components of the integrated MRI and navigation based hydrophone mapping system.

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