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Abstract #4194

Mapping Gadolinium Entry and Clearance from the Brain using Dynamic MRI

Payam Nahavandi1, Ian F Harrison1, May Z Thin1, John J Connell1, Ozama Ismail1, Yolanda Ohene1, Jack A Wells1, and Mark F Lythgoe1

1Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom

Recently, evidence for gadolinium retention in the brain was provided, raising concerns regarding the safety of these agents. This accumulation raised important questions, most crucially, by which pathway does gadolinium enter the brain. We provide insight into this by dynamic monitoring of the infiltration and clearance of gadolinium into the brain parenchyma following an IV injection. Following gadolinium injection, inflow of contrast into the cerebrospinal fluid spaces was prominent. 25mins post injection, contrast enhancement is detected in the periventricular regions and hypothalamus. This finding provides insight into the entry routes by which gadolinium infiltrates the brain following a systemic administration.

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