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Abstract #4242

Optimized parameters for MP2RAGE images on 7-T MRI

Uksu Choi1,2, Hirokazu Kawaguchi3, Yuichiro Matsuoka1,2, Tobias Kober4,5,6, and Ikuhiro Kida1,2

1Center for Information and Neural Networks, National Institute of Information and Communications Technology, Osaka, Japan, 2Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, 3Siemens Healthcare K.K., Osaka, Japan, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, University Hospital (CHUV), Lausanne, Switzerland, 6LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

The MP2RAGE sequence at ultra-high magnetic fields can be advantageous for investigation of microstructural changes because of reduced B1 inhomogeneity and images with different contrasts (uniform (UNI), T1, and fluid and white matter suppression (FLAWS)). In this study, we used several evaluative methods to optimize the inversion times and flip angles for UNI, T1, and FLAWS images of the MP2RAGE sequence at 7 T. We found the optimized inversion times with flip angles for UNI and T1 images, but different parameters for FLAWS images. The results suggested that different parameters of MP2RAGE at 7 T should be applied for different contrast types.

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