Abstract #4243

B1- and Fat-Corrected T1 Mapping Using Chemical-Shift Encoded MRI

Nathan T Roberts¹, Timothy J Colgan², Xiaoke Wang^2,3, Diego Hernando^2,4, and Scott B Reeder^2,3,4,5,6

¹University of Wisconsin Madison, Madison, WI, United States, ²Radiology, University of Wisconsin Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin Madison, Madison, WI, United States, ⁴Medical Physics, University of Wisconsin Madison, Madison, WI, United States, ⁵Medicine, University of Wisconsin Madison, Madison, WI, United States, ⁶Emergency Medicine, University of Wisconsin Madison, Madison, WI, United States

Spatially varying B₁ inhomogeneities and fat content are well known to be confounders of quantitative T₁ mapping that use multi flip angle techniques. Separate B₁ calibration maps can be acquired to correct flip angle errors cause by B₁ inhomogeneities, but this requires an additional acquisition. In this work we consider an alternative approach that acquires variable flip angles and variable repetition times, and simultaneously estimates B₁ inhomogeneity, T₁, fat-fraction and R₂*. The feasibility and noise performance of this approach are evaluated using theoretical Cramer-Rao Lower Bound analysis and simulations. Our results demonstrate that this approach is feasible, but suffers from relatively poor noise performance at typical acquisition parameters.

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