Quantifying the effect of self-diffusion on multi-parametric sequences, such as those used for Magnetic Resonance Fingerprinting (MRF) is important to increase the accuracy of dictionary based parameter estimation. To quantify diffusion, we propose a signal simulation approach, which replaces the Bloch equation with the Bloch-Torrey equation, and accounts for protocol and scan dependent parameters. We apply this framework on a Multi Spin Echo (MSE) protocol and quantify the diffusion encoding introduced by the spoiler gradients in this sequence. We further show that increasing the spoiler strength would allow detecting diffusion by including the diffusion effect in the dictionary.
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