Abstract #4319

Development of single-sided portable NMR methods for the sensing of mammographic density

Patricia O'Gorman¹, Monique C Tourell¹, Tonima S Ali ¹, Honor J Hugo ², Thomas Lloyd ³, Erik W Thompson ², and Konstantin I Momot¹

¹School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, Brisbane, Australia, ²School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia, ³Radiology, Princess Alexandra Hospital, Woolloongabba, Australia

Single-sided NMR was used to investigate the ability of spin-relaxation time constants to distinguish between regions of low and high mammographic density in human breast tissue. Measurements were performed on breast slices obtained from women undergoing breast reduction surgery or prophylactic mastectomy. T₁ values in regions of high mammographic density were found to be significantly different to those measured in regions of low mammographic density. The findings suggest that portable NMR may be suitable for quantification of mammographic density in the breast tissue, presenting a promising and low-cost means of MD assessment in vivo without the use of ionising radiation.

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