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Abstract #4320

Repeatability of 3D MR Fingerprinting Measurements in Normal Breast Tissue

Ananya Panda1, Yong Chen2, Satyam Ghodasara3, Katherine Wright1, Nicole Seiberlich4,5, Mark Alan Griswold1,4,5, and Vikas Gulani1,4,5

1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, University of North Carolina, Chapel Hill, NC, United States, 3Case Western School of Medicine, Cleveland, OH, United States, 4Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 5Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

3D Breast Magnetic Resonance Fingerprinting (MRF) allows simultaneous breast tissue T1 and T2 mapping. In this study, same session repeatability of 3D MRF technique in normal breast tissue was evaluated (test/retest 10 minutes apart) and in two consecutive visits. The within subject coefficient of variance (wCV) for two visit scans was < 6% for T1 and < 5% for T2. The wCV for test-retest scan for T1 was <5% and for T2 was 6.5%. One-week repeatability of 3D MRF was good for both T1 and T2 (ICC T1: 0.81 T2: 0.88 at second visit). These variations are smaller than observed inter-subject variability. Thus breast MRF may be useful for longitudinal patient follow-up.

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