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Abstract #4324

3D MRI for Quantitative Analysis of Quadrant Percent Density (QPD): Correlation with Location of Breast Cancer Growing in Different Quadrants

Jeon-Hor Chen1,2, Siwa Chan3, Yang Zhang1, Dah-Cherng Yeh4, and Min-Ying Su1

1Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States, 2Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan, 3Department of Radiology, Tzu-Chi General Hospital, Taichung, Taiwan, 4Breast Center, Tzu-Chi General Hospital, Taichung, Taiwan

We applied an MR-based quadrant percent density (QPD) method to investigate the association between the occurrence of cancer and the amount of dense tissue. Computer-aided method was applied to segment the breast and dense tissue, and then a breast was divided into four quadrants using nipple, centroid, and chestwall as the anatomic landmarks. In a total of 206 women, 88 (42.7%) had cancer growing in the upper-outer quadrant. Only 42 (20.4%) women had cancer growing in the quadrant with the highest QPD, suggesting that the amount of dense tissue cannot explain the disproportional occurrence of breast cancer in different quadrants.

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