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Abstract #4325

Correlation of Breast Stiffness Measured by Ultrasound with Breast Density Measured on MRI Matched by Using a Prone-Supine Deformation Model

Jeon-Hor Chen1,2, Siwa Chan3, Yang Zhang1, Dah-Cherng Yeh4, and Min-Ying Su1

1Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States, 2Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan, 3Department of Radiology, Tzu-Chi General Hospital, Taichung, Taiwan, 4Breast Center, Tzu-Chi General Hospital, Taichung, Taiwan

We correlated breast tissue stiffness measured by US elastography with the MR-measured density from the whole breast and the tissue in the US stiffness measurement window. Twenty women were studied, and only the normal breast was analyzed. A finite element model was applied to deform the prone MRI to match with supine US images by using the inversed gravity loaded transformation to locate the corresponding tissue region. There were no correlation between breast stiffness and the whole breast percent density (r=-0.09) and the local percent density (r=-0.12), suggesting that breast density and stiffness may be independent cancer risk factors.

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