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Abstract #4331

The Effect of Intravenous Administration of  a Gadolinium-Based Contrast Agent on Breast  Diffusion Tensor Imaging: Qualitative and Quantitative Evaluation.

Anabel M. Scaranelo1,2,3, Hadassa Degani4, Dov Grobgeld4, Nancy Talbot5, Karen Bodolai5, and Edna Furman-Haran4

1Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada, 2Marvelle Koffler Breast Centre, Sinai Health System, Toronto, ON, Canada, 3Toronto Joint Department of Medical Imaging, University of Toronto, Toronto, ON, Canada, 4Weizmann Institute of Science, Rehovot, Israel, 5Toronto Joint Department of Medical Imaging, University Health Network, Toronto, ON, Canada

We have investigated whether the values of the diffusion tensor imaging (DTI) parameters of breast normal tissue, as well as of benign and cancer lesions are affected by gadolinium-based contrast administration. Changes in the DTI parameters and consequently in DTI-based lesion size were evaluated pre and post dynamic contrast enhanced (DCE) MRI. Results indicated that scanning with DTI post DCE did not impact the diffusion parameters in breast normal tissue and benign lesions and the lesions’ size but revealed a significant reduction of the diffusion coefficients in breast cancers, suggesting potential improvement of DTI diagnostic specificity post-contrast.

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