Meeting Banner
Abstract #4353

Longitudinal assessment of changes in lung microstructure in idiopathic pulmonary fibrosis with hyperpolarized gas diffusion-weighted MRI

Ho-Fung Chan1, Nicholas D. Weatherley1, Neil J. Stewart1, Guilhem J. Collier1, Stephen Bianchi2, and Jim M. Wild1

1Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, 2Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

Apparent diffusion coefficient (ADC) calculated from hyperpolarized gas diffusion-weighted (DW)-MRI has been shown to be elevated in lungs afflicted with idiopathic pulmonary fibrosis (IPF). This work assesses the sensitivity of 3He DW-MRI metrics to longitudinal changes in IPF patients by evaluating 3He ADC and mean diffusive length scale (LmD) from the stretched exponential model at baseline, 6 and 12 months. ADC was not significantly different between visits, but a statistically significant increase of 13 µm in Lm­D was observed after 12 months suggesting multiple b-value DW-MRI is sensitive to progressive microstructural changes in the lungs in IPF.

This abstract and the presentation materials are available to members only; a login is required.

Join Here