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Abstract #4358

Correction for Ventilation Quantification Errors due to Registration in Pulmonary Lung MRI Fourier Decomposition

Filip Klimeš1,2, Andreas Voskrebenzev1,2, Marcel Gutberlet1,2, Agilo Kern1,2, Lea Behrendt1,2, Till Kaireit1,2, Alexander Rotärmel1,2, Julius Renne1,2, Christian Schönfeld1,2, Frank Wacker1,2, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany

Ventilation-perfusion (V/Q) scan plays an important role in the assessment of lung function. Currently, Fourier Decomposition (FD), a method for simultaneous ventilation and perfusion measurement, uses fractional ventilation (FV) as a semi-quantitative measurement of lung ventilation. Just recently, a multi-echo spoiled gradient echo sequence method for regional alveolar ventilation (AV) measurement with FD was presented. This study demonstrates that both methods suffer from an artificial proton amount change during registration, which affects quantification. Correction factors are derived for both methods and used to compare AV and FV measurement. Additionally, the regional influence of T2* correction is assessed.

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