Abstract #4358

Correction for Ventilation Quantification Errors due to Registration in Pulmonary Lung MRI Fourier Decomposition

Filip Klimeš^1,2, Andreas Voskrebenzev^1,2, Marcel Gutberlet^1,2, Agilo Kern^1,2, Lea Behrendt^1,2, Till Kaireit^1,2, Alexander Rotärmel^1,2, Julius Renne^1,2, Christian Schönfeld^1,2, Frank Wacker^1,2, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hanover, Germany

Ventilation-perfusion (V/Q) scan plays an important role in the assessment of lung function. Currently, Fourier Decomposition (FD), a method for simultaneous ventilation and perfusion measurement, uses fractional ventilation (FV) as a semi-quantitative measurement of lung ventilation. Just recently, a multi-echo spoiled gradient echo sequence method for regional alveolar ventilation (AV) measurement with FD was presented. This study demonstrates that both methods suffer from an artificial proton amount change during registration, which affects quantification. Correction factors are derived for both methods and used to compare AV and FV measurement. Additionally, the regional influence of T₂* correction is assessed.

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