Abstract #4359

Multiparametric Approach by Quantitatively Assessed Dynamic First-Pass Contrast-Enhanced Perfusion MRI with FDG-PET/CT: Capability for Therapeutic Response Prediction in Non-Small Cell Lung Cancer After Conservative Therapy

Yoshiharu Ohno^1,2, Masao Yui³, Shigeharu Ohyu³, Yuji Kishida⁴, Shinichiro Seki^1,2, Katsusuke Kyotani⁵, and Takeshi Yoshikawa^1,2

¹Division of Functional and Diagnostic Imaging Research, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Advanced Biomedical Imaging Research Center, Kobe University Graduate School of Medicine, Kobe, Japan, ³Toshiba Medical Systems Corporation, Otawara, Japan, ⁴Division of Radiology, Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan, ⁵Center for Radiology and Radiation Oncology, Kobe University Hospital, Kobe, Japan

To the best of our knowledge, no studies have been reported of a direct comparison of dynamic CE-perfusion MRI with PET/CT for therapeutic effect prediction for NSCLC patients treated with chemoradiotherapy. We hypothesized that multiparametric approach of quantitatively assessed dynamic CE-perfusion MRI with PET/CT have potential for better therapeutic effect prediction than single parametric methods by both modalities in NSCLC patients treated with chemoradiotherapy. The purpose of this study was therefore to directly compare the capability for therapeutic response prediction by among quantitatively assessed dynamic CE-perfusion MRI, FDG-PET/CT and multiparametric approach by both modalities in NSCLC patients treated with chemoradiotherapy.

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