Prostate cancer(PCa) is one of the leading causes of cancer-related deaths in North American men. Nodal metastases occur in 3-42% of men with clinically localized prostate cancer and the presence of nodal metastases has a strong negative impact on survival. Lymph node staging plays an important role in planning initial management in nonmetastatic PCa. Early detection and resection are important for staging and for the prognosis. We evaluated the diagnostic performance of MR elastography (MRE) in patients with PCa. Results from 33 patients with PCa show that MRE at both of 60Hz and 90Hz has the potential to be a useful technique for predicting PCa lymph node metastases and to establish prognosis and treatment planning.