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Abstract #4388

Diagnostic performance of qualitative and quantitative 3T DCE-MRI parameters of prostate cancer lesions in transition and peripheral zone stratified by pathology Gleason score and PI-RADSv2 score

Sohrab Afshari Mirak1, Kyung Hyun Sung2, Amirhossein Mohammadian Bajgiran1, Nazanin Hajarol Asvadi1, Ely R Felker1, Preeti Ahuja1, Anthony Sisk3, Robert Reiter4, and Steven Raman1

1Radiology, David Geffen school of Medicine at UCLA, LOS ANGELES, CA, United States, 2Radiological Sciences and Bioengineering, David Geffen school of Medicine at UCLA, LOS ANGELES, CA, United States, 3Pathology, David Geffen school of Medicine at UCLA, LOS ANGELES, CA, United States, 4Urology, David Geffen school of Medicine at UCLA, LOS ANGELES, CA, United States

We investigated the diagnostic performance of qualitative and quantitative parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of prostate cancer (PCa) in 238 patients with 303 lesions located in transition (TZ) and peripheral zone (PZ) stratified by pathology Gleason score (GS) and PI-RADSv2 score with whole mount histopathology validation. There was a significant difference in qualitative and quantitative values between low and high-grade tumors and PI-RADSv2 scores in PZ PCa lesions. However, for tumors located in TZ, only DCE curve type was significantly different between low and high-grade PCa.

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