Abstract #4389

Diffusion-weighted Imaging and Dynamic Contrast-enhanced Imaging Distinguish Inflammation from Low Grade Cancer and Normal Tissue in the Peripheral Zone of the Prostate

Natalie Korn^1,2, Olga Starobinets^1,2, Jeffry Simko³, John Kurhanewicz^1,2, and Susan M Noworolski^1,2

¹Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA, United States, ²The Graduate Group in Bioengineering, Universities of California at Berkeley and San Francisco, Berkeley and San Francisco, CA, United States, ³Pathology, University of California at San Francisco, San Francisco, CA, United States

Inflammation can complicate the ability to distinguish normal tissue from cancer in the peripheral zone of the prostate. In this work, we show that a multiparametric MRI including dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging can distinguish inflammation in the peripheral zone of the prostate from both low-grade prostate cancer and normal tissue. A depth-restricted decision tree built on the apparent diffusion coefficient (ADC) and maximal wash-in slope on DCE correctly classified 79.6% of regions of normal tissue, inflammation, and low-grade cancer in the peripheral zone of the prostate based on pathologist-detailed regions on whole-mount resected glands.

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