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Abstract #4439

Initial enhancement in breast ultrafast DCE-MRI as a marker for malignancy

Federico Pineda1, Ty O Easley1, Hiroyuki Abe1, David Schacht1, and Gregory Karczmar1

1Radiology, University of Chicago, Chicago, IL, United States

59 patients with dense breasts and suspicious findings on mammography underwent pre-biopsy DCE-MRI including high-temporal-resolution (‘ultrafast’) imaging during the first minute post-contrast. Parameters descriptive of early enhancement (initial slope and initial area under the gadolinium curve) were significantly different between benign and malignant lesions. Ultrafast imaging allowed for measurement of kinetic parameters with respect to the bolus time-of-arrival in the breast; removing dependence on variables such as cardiac output. High-temporal resolution DCE allows accurate measurements of very early enhancement kinetics, when differences between benign and malignant lesions may be largest; this could aid in the evaluation of suspicious breast lesions.

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