Abstract #4440

Lymph Node Multi-parametric MRI Is a Strong Predictor of Pathologic Response to Chemotherapy: ACRIN/I-SPY Trial

Silu Han^1,2, Renee F. Cattell^1,2, James J. Kang¹, Thomas Ren¹, Pauline B. Huang¹, Haifang Li¹, Jules A. Cohen³, Paul Fisher¹, Roxanne Palermo¹, and Tim Q. Duong¹

¹Department of Radiology, Stony Brook University, Stony Brook, NY, United States, ²Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ³Department of Medicine, Stony Brook University, Stony Brook, NY, United States

MRI primary breast lesion volume has been shown to be a strong predictor in the response to chemotherapy for invasive breast cancer. However, the prediction accuracy remains low. In this study, we investigated the feasibility of using lymph node volume and signal enhancement ratio as predictors of the chemotherapy response. The result shows that the lymph nodes signal-enhancement ratio is a stronger predictor than lymph node volume and primary in-breast lesion volume.

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