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Abstract #4442

Characterize Tumor Cellularity in Breast Cancer with Diffusion MRI

Zezhong Ye1, Na Zhao2, Joshua Lin1, Qingsong Yang2, Jeff Viox1, Peng Sun1, Jianping Lu2, and Song-Kwei Song1

1Radiology, Washington University School of Medicine, St. Louis, MO, United States, 2Radiology, Changhai Hospital, Shanghai, China

Recent consensus suggested breast MRI lacks necessary sensitivity or specificity to detect breast cancer. MRI may over-diagnose breast cancer and result in over-treatment. The novel diffusion MRI histology (D-Histo) method demonstrated its ability to accurately locate lesion and quantify cancer cellularity and afforded greater sensitivity and specificity than ADC did in distinguishing between tumor and benign tissues. D-Histo’s improved diagnostic accuracy thus better guides treatment planning, and more accurately measures treatment efficacy.

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