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Abstract #4443

Intravoxel incoherent motion (IVIM) and non-Gaussian diffusion MRI of the lactating breast

Mami Iima1,2, Masako Kataoka1, Rena Sakaguchi1, Shotaro Kanao1, Natsuko Onishi1, Makiko Kawai1, Katsutoshi Murata3, and Kaori Togashi1

1Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan, 3Siemens Healthcare K.K., Tokyo, Japan

The effect of breastfeeding on IVIM and non-Gaussian diffusion MRI was investigated. ADC0 and sADC values significantly decreased (P < 0.001 and P < 0.001) while K values significantly increased (P < 0.05) post-breastfeeding. fIVIM values significantly increased after breastfeeding (P < 0.01). No significant difference was found in D* values. There was significant heterogeneity in ADC0 maps post-breastfeeding, both in retroareolar and segmental scores (P < 0.0001 and = 0.0001). IVIM and non-Gaussian diffusion parameters significantly changed between pre- and post-breastfeeding status, and care needs to be taken in interpreting DWI data in lactating breasts.

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