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Abstract #4445

Effect of Contrast Dose on Diagnostic Performance in DCE-MR Breast Imaging

Lawrence Dougherty1, Elizabeth S. McDonald1, Gamaliel Isaac1, Thuy-My Thi Le1, and Mark A. Rosen1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

A retrospective reader study was performed to assess breast MRI diagnostic performance as a function of contrast dose. There was an increase in sensitivity for malignancy with increasing contrast dose with no significant decrease in specificity. Greater confidence in the lesion assessment was also shown by the inter-observer agreement, which increased at the higher doses. Diagnostic performance of DCE-MR breast imaging was greater when subjects received a higher gadolinium dose than the current standard of 0.10 mmol/kg.

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