A retrospective reader study was performed to assess breast MRI diagnostic performance as a function of contrast dose. There was an increase in sensitivity for malignancy with increasing contrast dose with no significant decrease in specificity. Greater confidence in the lesion assessment was also shown by the inter-observer agreement, which increased at the higher doses. Diagnostic performance of DCE-MR breast imaging was greater when subjects received a higher gadolinium dose than the current standard of 0.10 mmol/kg.
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