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Abstract #4453

Magnetization Transfer MRI of Breast Cancer Response to Neoadjuvant Therapy: Preliminary Results

Jack Virostko1, Anna Sorace1, Chengyue Wu1, Stephanie Barnes1, Angela Jarrett1, Debra Patt2, Boone Goodgame3, Sarah Avery4, and Thomas E Yankeelov1

1University of Texas at Austin, Austin, TX, United States, 2Texas Oncology, Austin, TX, United States, 3Seton Hospital, Austin, TX, United States, 4Austin Radiological Association, Austin, TX, United States

Magnetization transfer MRI (MT-MRI) may be sensitive to changes in the macromolecular content of tumors and the extracellular matrix that occur during neoadjuvant therapy for breast cancer. We demonstrate in a pilot population of breast cancer patients that the magnetization transfer ratio declines after the first cycle of chemotherapy in women who achieve response to therapy, while the magnetization transfer ratio increases in tumors that do not respond to therapy.

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