Magnetization transfer MRI (MT-MRI) may be sensitive to changes in the macromolecular content of tumors and the extracellular matrix that occur during neoadjuvant therapy for breast cancer. We demonstrate in a pilot population of breast cancer patients that the magnetization transfer ratio declines after the first cycle of chemotherapy in women who achieve response to therapy, while the magnetization transfer ratio increases in tumors that do not respond to therapy.
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