Abstract #4456

One millimeter isotropic breast DWI combining readout-segmented EPI and super-resolution

Maya DELBANY¹, Julie POUJOL¹, Aurélien BUSTIN², Isabelle THOMASSIN-NAGGARA^3,4, Jacques FELBLINGER^1,5, Pierre-André VUISSOZ¹, and Freddy ODILLE^1,5

¹IADI, U947, Université de Lorraine, INSERM, Nancy, France, ²School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ³Assistance Publique-Hopitaux de Paris (AP-HP), Hôpital Tenon, Service d'Imagerie, 4 rue de la Chine, Paris, France, ⁴Sorbonne Universités, UPMC Univ Paris 06, Institut Universitaire de Cancérologie, Paris, France, ⁵CIC1433, CHRU Nancy, INSERM, Université de Lorraine, Nancy, France

High-resolution diffusion-weighted imaging (DWI) has the potential to improve the specificity of breast MRI. In this work a method is proposed for 3D isotropic DWI of the whole breasts. Three breast DWI datasets were acquired using a readout-segmented DW-EPI sequence (rs-EPI) with thick slices (3 mm) and 1mm-shifts in the slice direction. A high isotropic resolution (1x1x1 mm³) DWI dataset was reconstructed using a super-resolution reconstruction (SRR) on the low-resolution anisotropic acquisiitons, with different regularization schemes (Tikhonov and Beltrami, an edge-preserving constraint). This study shows the benefit of this strategy compared to native acquisitions with 1 mm slice thickness. A quantitative SNR evaluation is presented.

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