Abstract #4457

Addition of in-vivo proton MRS to DCEMRI increases the sensitivity of cancer detection in breast cancer patients especially in cases of indeterminate dynamic MRI findings.

Naranamangalam R Jagannathan¹, Khusbhu Agarwal¹, Uma Sharma¹, Smriti Hari², Vurthaluru Seenu³, Sandeep Mathur⁴, Siddhartha D Gupta⁴, and Rajinder Parshad³

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Radiology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Surgery, All India Institute of Medical Sciences, New Delhi, India, ⁴Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

Potential of addition of in-vivo proton (¹H) MRS to DCEMRI data especially in indeterminate DCE findings was evaluated. MRS and DCEMRI data of 56 breast cancer patients were included in the analysis. 47/56 cases showed type III curve indicating cancer with a sensitivity of 83.9%. MRS showed true positive findings of cancer in 44/47 cases. Among 9 indeterminate DCE cases, MRS was positive for cancer in 6 cases, implying that 50/56 cases were true positive for cancer with 89.3% sensitivity. Addition of MRS to DCEMRI data increases the sensitivity of cancer detection especially in indeterminate DCE findings.

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