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Abstract #4459

Comparison of 1.0M Gadobutrol and 0.5M Gadoteridol for Kinetic Parameters on Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging at 3T

Hajime Sagawa1, Masako Kataoka1, Shotaro Kanao2, Natsuko Onishi3, Maya Honda2, Dominik Nickel4, Masakazu Toi5, Katsuhiko Ueda1, and Kaori Togashi2

1Division of Clinical Radiology Service, Kyoto University Hospital, Kyoto, Japan, 2Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan, 3Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 5Department of Breast Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan

The contrast effects of 1.0M gadobutrol were compared to that of 0.5M gadoteridol in breast cancer at 3T using hybrid MRI protocol which combined conventional DCE (C-DCE) with ultrafast DCE (UF-DCE). The significant differences were observed only in UF-DCE, maximum enhancement ratio (MER) and maximum slope (MS). The slightly higher peak relative enhancement produced by gadobutrol compared with gadoteridol might help in the detection and evaluation of breast lesions in the earlier phases.

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