Abstract #4460

Quantitative Analysis of Peri-Tumor Interface Fat and the Volumetric Fat Percentage and Contrast Enhancement in Three Peri-Tumoral Shells to Differentiate Molecular Subtypes of Breast Cancer

Jeon-Hor Chen^1,2, Yang Zhang¹, Siwa Chan³, Dah-Cherng Yeh⁴, and Min-Ying Su¹

¹Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California Irvine, Irvine, CA, United States, ²Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan, ³Department of Radiology, Tzu-Chi General Hospital, Taichung, Taiwan, ⁴Breast Center, Tzu-Chi General Hospital, Taichung, Taiwan

A 3D morphological analysis method was developed to analyze the fat content on tumor boundary interface and in different peri-tumoral shells away from the tumor. A total of 114 mass type breast cancers were analyzed, including 87 HR(+), 13 HR(-)HER2(+), and 14 TN. The volumetric fat percentage in three shells surrounding the tumor: 150%-100%, 200%-150%, 250%-200% of the tumor convex hall were measured, also the mean contrast enhancement in fibroglandular tissue contained within three shells were measured. The peri-tumor fat content and contrast enhancement is the highest in the most aggressive TN tumors compared to other subtypes.

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