Abstract #4463

High Ventilation Percent on Hyperpolarized Helium-3 MRI is Associated with Reduced One-Year Risk of Asthma Exacerbation

David Mummy^1,2, Wei Zha², Shannon Kehoe³, Guy Olson⁴, Ronald Sorkness^5,6,7, Nizar Jarjour⁶, Mark Schiebler⁸, Loren Denlinger⁶, Michael Evans⁹, and Sean Fain^1,2,8

¹Biomedical Engineering, University of Wisconsin -- Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin -- Madison, Madison, WI, United States, ³Kinesiology, University of Wisconsin -- Madison, Madison, WI, United States, ⁴Neurobiology, University of Wisconsin -- Madison, Madison, WI, United States, ⁵Pharmacy, University of Wisconsin -- Madison, Madison, WI, United States, ⁶Allergy, Pulmonary & Critical Care Medicine, University of Wisconsin -- Madison, Madison, WI, United States, ⁷Pediatrics, University of Wisconsin -- Madison, Madison, WI, United States, ⁸Radiology, University of Wisconsin -- Madison, Madison, WI, United States, ⁹Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States

We assessed the high ventilation percent (HVP) as well as the ventilation defect percent (VDP) on hyperpolarized (HP) ³He MRI and found that both measures were associated with exacerbation in the year following imaging, with the HVP exhibiting the stronger association. Both measures were strong predictors relative to other measures of lung function. These findings suggest that HVP is sensitive to one-year risk of asthma exacerbation and is a potential biomarker of asthma instability.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.