Meeting Banner
Abstract #4464

Bridging the gap between lung small conducting and acinar airways – combined in vivo lung morphometry with hyperpolarized 3He MRI and CT studies.

Dmitriy A Yablonskiy1, Alexander L Sukstanskii1, James D Quirk1, Chase Hall1, Mario Castro1, David S Gierada1, Vanessa Curtis1, Miranda Kirby2, Eric A Hoffman3, and Roger D Yusen1

1Washington University in St. Louis, St. Louis, MO, United States, 2UBC Center for Heart Lung Innovation, Vancouver, BC, Canada, 3University of Iowa, Iowa City, IA, United States

Air trapping (retention of inspired air during expiration) is usually associated with small conducting airways disease. However, limited information exists on integrity of acinar airways (i.e., alveolar ducts and sacs) in lung regions affected by air trapping. In this study we combine novel CT and MRI metrics to understand the sub-lobar level relationships between MR-derived acinar anatomy and CT-based air trapping metrics. We studied healthy non-smokers, smokers and COPD subjects and found significant associations between air trapping and acinar airways shallowing in upper and middle lungs in all groups but very little association in lower lung, except for COPD patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here