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Abstract #4465

Comparison of CT ventilation and Hyperpolarised Gas MRI: Effects of breathing manoeuvre

Bilal A. Tahir1,2, Helen Marshall1, Paul J. Hughes1, Guilhem Collier1, Rob H. Ireland2, and Jim M. Wild1

1Polaris, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Clinical Oncology, University of Sheffield, Sheffield, United Kingdom

Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung ‘ventilation’. However, this technique requires validation against established ventilation imaging modalities such as hyperpolarized gas MRI. Variations in lung inflation may affect regional lung function as imaged with the two modalities. Here, we evaluate the impact of the lung inflation level during MRI when comparing gas MRI and CT ventilation for a cohort of 7 patients with asthma.

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