Abstract #4466

Mapping of pseudo-compliance using hyperpolarized 129Xe morphometry in the rat lung

Andras Lindenmaier^1,2, Brandon Zanette^1,2, Elaine Stirrat¹, Brian Kavanagh^1,3,4, and Giles Santyr^1,2

¹Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, ²Medical Biophysics, University of Toronto, Toronto, ON, Canada, ³Anesthesia, University of Toronto, Toronto, ON, Canada, ⁴Critical Care Medicine, Hospital for Sick Children, Toronto, ON, Canada

Performing 129Xe morphometry at multiple pressures allows for direct mapping of microstructural changes and micromechanical properties of the lung (eg. pseudo-compliance) in both health and disease. In the present study, the effects of posture and gravity on the linear portion of lung pseudo-compliance are investigated using this approach in healthy mechanically-ventilated rats. Spatial gradients in lung pseudo-compliance due to gravity and posture are shown to vary, consistent with the expectations that the lungs are denser dorsally due to the weight above. Scaled regional pseudo-compliance is shown to be in agreement with whole lung compliance measured using 1H MRI.

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