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Abstract #4472

Retrospective removal of gas-phase signal from pulmonary dissolved-phase Hyperpolarized 129Xe images

Jeff Kammerman1, Andrew D Hahn1, and Sean B Fain1

1Department of Medical Physics, University of Wisconsin, Madison, Madison, WI, United States

Dissolved-phase hyperpolarized xenon-129 imaging provides regional information on gas exchange between the lung airspaces, parenchymal tissues, and blood stream. Current spectroscopic techniques require that the dissolved-phase 129Xe signal be acquired with no gas-phase excitation. However, the short T2* of the dissolved-phase requires short RF pulses, limiting the spectral selectivity achievable. This, combined with the high spin density of the gas-phase relative to the dissolved-phase, leads to unwanted gas-phase excitation. In this work, we retrospectively remove contaminant gas-phase signal from both simulated and human subject images using a multi-echo acquisition with iterative estimation of the contaminant gas-phase signal.

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