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Abstract #4471

Hyperpolarized 129Xe Gas Exchange Imaging of the Human Lung using IDEAL with Spiral k-space Sampling

Ozkan Doganay1,2, Mitchell Chen2, Tahreema Matin2, Marzia Rigolli3, Julie-Ann Phillips2, Anthony McIntyre2, and Fergus V. Gleeson1,2

1Department of Oncology, University of Oxford, Oxford, United Kingdom, 2Department of Radiology, The Churchill Hospital, Oxford, United Kingdom, 3Division of Cardiovascular Medicine, University of Oxford Centre for Clinical Magnetic Resonance Research, Oxford, United Kingdom

This proof of concept study describes implementation and analysis of an IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least-square estimation) based imaging technique for imaging hyperpolarized Xenon-129 (HPX) gas ventilation and dissolved phase compartments in human lungs. The time-series IDEAL imaging approach was tested in a healthy subject corroborating with Bloch equations and a numerical gas-exchange model showing that HPX gas ventilation and dissolved phase compartment images can be obtained, and the gas-transfer dynamics can be measured, in a single breath-hold interval of 8 seconds using 1L of HPX gas with polarization of ~10%.

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