Abstract #4470

Dynamic MRI of Hyperpolarized Xenon-129 Uptake in the Human Kidney Using a Dedicated Transmission-Only-Reception-Only Array at 3 Tesla

Jorge Chacon-Caldera^1,2, Adam Maunder², Madhwesha Rao², Graham Norquay², Oliver I. Rodgers², Matthew Clemence³, Claudio Puddu², Lothar R. Schad¹, and Jim M. Wild²

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²POLARIS, Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom, ³Philips Healthcare, Guildford, United Kingdom

Dissolved hyperpolarized ¹²⁹Xe MRI is an emerging technique. Inhaled xenon dissolves in the blood in the lungs and with a long T₁ (8s) has the potential for imaging other organs that are well perfused such as the kidneys. An RF coil array was designed with an anatomically focused transmit field to avoid RF depolarization of dissolved xenon in its transit from the lungs whilst providing local sensitivity over the kidney. Dynamic imaging of dissolved ¹²⁹Xe in kidneys was performed in 2 healthy volunteers. The signal evolution in the cortex was obtained which might provide novel physiological insight into kidney physiology.

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