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Abstract #4470

Dynamic MRI of Hyperpolarized Xenon-129 Uptake in the Human Kidney Using a Dedicated Transmission-Only-Reception-Only Array at 3 Tesla

Jorge Chacon-Caldera1,2, Adam Maunder2, Madhwesha Rao2, Graham Norquay2, Oliver I. Rodgers2, Matthew Clemence3, Claudio Puddu2, Lothar R. Schad1, and Jim M. Wild2

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2POLARIS, Unit of Academic Radiology, University of Sheffield, Sheffield, United Kingdom, 3Philips Healthcare, Guildford, United Kingdom

Dissolved hyperpolarized 129Xe MRI is an emerging technique. Inhaled xenon dissolves in the blood in the lungs and with a long T1 (8s) has the potential for imaging other organs that are well perfused such as the kidneys. An RF coil array was designed with an anatomically focused transmit field to avoid RF depolarization of dissolved xenon in its transit from the lungs whilst providing local sensitivity over the kidney. Dynamic imaging of dissolved 129Xe in kidneys was performed in 2 healthy volunteers. The signal evolution in the cortex was obtained which might provide novel physiological insight into kidney physiology.

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