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Abstract #4469

Clinical Translation of 3D Spiral-IDEAL for Single Breath-hold Imaging of Gas and Dissolved-Phase Hyperpolarized 129Xe in Human Lungs

Brandon Zanette1,2 and Giles Santyr1,2

1Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, Univeristy of Toronto, Toronto, ON, Canada

Spiral-IDEAL is a fast and efficient technique for imaging dissolved-phase hyperpolarized 129Xe in tissue/blood plasma (T/P) and red blood cell (RBC) compartments of the lung. Previously, spiral-IDEAL has been limited to pre-clinical rodent models using multi-breath techniques not suitable for human subjects. In this work we optimize and demonstrate clinical translation of spiral-IDEAL for single breath-hold 129Xe imaging of human subjects. We compare and contrast several interleaved imaging strategies. Furthermore, we also demonstrate 3D spiral-IDEAL for simultaneous volumetric imaging of gas, T/P, and RBC compartments.

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