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Abstract #4468

An Interleaved Spiral-IDEAL Approach for Physiological Gas Exchange Imaging in Humans using a Single Breath-hold of Hyperpolarized 129Xe

Brandon Zanette1,2 and Giles Santyr1,2

1Translational Medicine Program, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, 2Department of Medical Biophysics, Univeristy of Toronto, Toronto, ON, Canada

Pulmonary disease involving lung injury (e.g. ventilator-induced lung injury, radiation-induced lung injury, interstitial lung disease) can lead to pulmonary dysfunction which may not be detectable using proton pulmonary magnetic resonance imaging or ventilation imaging with hyperpolarized noble gases. The solubility of 129Xe in biological tissues and resultant chemical shifts allow for the quantification of physiological gas exchange which hold promise for the clinical evaluation of early pulmonary dysfunction. In this work we demonstrate an approach for dissolved-phase 129Xe gas exchange imaging within a single breath-hold in healthy human volunteers.

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