Abstract #4474

Voxel-based mapping of lung microstructural parameters using hyperpolarized 129Xe dissolved-phase imaging in healthy volunteers and chronic obstructive pulmonary disease patients

Agilo Luitger Kern^1,2, Marcel Gutberlet^1,2, Andreas Voskrebenzev^1,2, Filip Klimes^1,2, Alexander Rotärmel^1,2, Frank Wacker^1,2, Jens Hohlfeld^2,3, and Jens Vogel-Claussen^1,2

¹Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, ²Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, ³Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Chemical shift saturation recovery (CSSR) spectroscopy is a method, which is able to assess lung microstructure using ¹²⁹Xe gas uptake and to discriminate between healthy volunteers and chronic obstructive pulmonary disease (COPD) patients. However, the absent spatial encoding of standard CSSR spectroscopy poses a limitation of the method for detecting early disease. A method for voxel-based mapping of lung microstructural parameters is proposed. Preliminary data from a study in healthy volunteers and COPD patients employing both CSSR mapping and spectroscopy are presented. Whole-lung median wall thickness and surface-to-volume ratio are highly reproducible and correlate significantly with global values from spectroscopy in COPD patients.

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