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Abstract #4474

Voxel-based mapping of lung microstructural parameters using hyperpolarized 129Xe dissolved-phase imaging in healthy volunteers and chronic obstructive pulmonary disease patients

Agilo Luitger Kern1,2, Marcel Gutberlet1,2, Andreas Voskrebenzev1,2, Filip Klimes1,2, Alexander Rotärmel1,2, Frank Wacker1,2, Jens Hohlfeld2,3, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

Chemical shift saturation recovery (CSSR) spectroscopy is a method, which is able to assess lung microstructure using 129Xe gas uptake and to discriminate between healthy volunteers and chronic obstructive pulmonary disease (COPD) patients. However, the absent spatial encoding of standard CSSR spectroscopy poses a limitation of the method for detecting early disease. A method for voxel-based mapping of lung microstructural parameters is proposed. Preliminary data from a study in healthy volunteers and COPD patients employing both CSSR mapping and spectroscopy are presented. Whole-lung median wall thickness and surface-to-volume ratio are highly reproducible and correlate significantly with global values from spectroscopy in COPD patients.

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