The NMR line shape in the lung parenchyma exhibits significant broadening due to numerous jumps in magnetic susceptibility. The purpose of this work was to extract this line shape from the 129Xe dissolved-phase spectrum. Free induction decays were acquired in healthy volunteers and COPD patients and a model function including two resonances and a superimposed frequency distribution was fitted to the time-domain data. Both second moment and skewness of the fitted frequency distribution were significantly elevated in COPD patients. The ratio of 129Xe in red blood cells and lung tissue was significantly reduced in COPD patients.