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Abstract #4475

Hyperpolarized 129Xe MR spectroscopy of the human lung in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD): investigation of lung microstructure

Agilo Luitger Kern1,2, Marcel Gutberlet1,2, Andreas Voskrebenzev1,2, Filip Klimes1,2, Frank Wacker1,2, Jens Hohlfeld2,3, and Jens Vogel-Claussen1,2

1Institute of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany, 2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany, 3Department of Clinical Airway Research, Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany

The NMR line shape in the lung parenchyma exhibits significant broadening due to numerous jumps in magnetic susceptibility. The purpose of this work was to extract this line shape from the 129Xe dissolved-phase spectrum. Free induction decays were acquired in healthy volunteers and COPD patients and a model function including two resonances and a superimposed frequency distribution was fitted to the time-domain data. Both second moment and skewness of the fitted frequency distribution were significantly elevated in COPD patients. The ratio of 129Xe in red blood cells and lung tissue was significantly reduced in COPD patients.

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