Abstract #4476

Quantifying Changes in Time-Resolved Hyperpolarized 129Xe Spectroscopy among Healthy Volunteers, Subjects with Idiopathic Pulmonary Fibrosis, and Subjects with Pulmonary Arterial Hypertension

Elianna Bier¹, Scott Robertson¹, Geoff Schrank¹, Craig Rackley¹, Joseph Mammarappallil¹, Sudarshan Rajagopal², H. Page McAdams¹, and Bastiaan Driehuys¹

¹Radiology, Duke University Medical Center, Durham, NC, United States, ²Cardiology, Duke University Medical Center, Durham, NC, United States

The temporal dynamics of ¹²⁹Xe spectroscopy were examined by collecting FIDs during inhalation, breath-hold, and exhalation. These FIDs were fit to a Voigt model to extract four spectral parameters (amplitude, chemical shift, linewidth, and phase) for the airspace, barrier, and RBC ¹²⁹Xe resonances. The RBC resonance parameters exhibited oscillations at the cardiac frequency which were quantified by peak-to-peak amplitudes. IPF subjects exhibited larger signal amplitude, chemical shift, and phase oscillations than healthy or PAH subjects. This indicates that ¹²⁹Xe transfer spectroscopy is differentially affected by cardiopulmonary dynamics such that the causes of gas exchange impairment can be distinguished.

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