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Abstract #4476

Quantifying Changes in Time-Resolved Hyperpolarized 129Xe Spectroscopy among Healthy Volunteers, Subjects with Idiopathic Pulmonary Fibrosis, and Subjects with Pulmonary Arterial Hypertension

Elianna Bier1, Scott Robertson1, Geoff Schrank1, Craig Rackley1, Joseph Mammarappallil1, Sudarshan Rajagopal2, H. Page McAdams1, and Bastiaan Driehuys1

1Radiology, Duke University Medical Center, Durham, NC, United States, 2Cardiology, Duke University Medical Center, Durham, NC, United States

The temporal dynamics of 129Xe spectroscopy were examined by collecting FIDs during inhalation, breath-hold, and exhalation. These FIDs were fit to a Voigt model to extract four spectral parameters (amplitude, chemical shift, linewidth, and phase) for the airspace, barrier, and RBC 129Xe resonances. The RBC resonance parameters exhibited oscillations at the cardiac frequency which were quantified by peak-to-peak amplitudes. IPF subjects exhibited larger signal amplitude, chemical shift, and phase oscillations than healthy or PAH subjects. This indicates that 129Xe transfer spectroscopy is differentially affected by cardiopulmonary dynamics such that the causes of gas exchange impairment can be distinguished.

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