Abstract #4478

A Clinical-Scale Thermally Polarized 129Xe Phantom for Quality Assurance in Multi-Center Hyperpolarized Gas MRI Trials

Naomi Morales Medina^1,2, Ziyi Wang^2,3, Mu He^2,4, Geoffry Schrank^2,5, John Nouls^2,5, Elianna A. Bier^2,5, Scott H. Robertson^1,2, Ralph Hashoian⁶, John Mugler⁷, and Bastiaan Driehuys^1,2,3,5

¹Medical Physics Graduate Program, Duke University, Durham, NC, United States, ²Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, ³Department of Biomedical Engineering, Duke University, Durham, NC, United States, ⁴Department of Electrical and Computer Engineering, Duke University, Durham, NC, United States, ⁵Department of Radiology, Duke University Medical Center, Durham, NC, United States, ⁶Clinical MR Solutions, Brookfield, WI, United States, ⁷Department of Radiology, University of Virginia, Charlottesville, VA, United States

Hyperpolarized ¹²⁹Xe-MRI is emerging as a promising method to quantify pulmonary function, but the transient nature of its signal makes routine quality assurance tasks challenging. With increasing interest in multi-center deployment of this technology, it is critical to develop tools to characterize ¹²⁹Xe imaging performance across sites and platforms. Here, we demonstrate a robust, portable, clinical-scale thermally-polarized ¹²⁹Xe phantom and integrated loader shell. Its utility is demonstrated for characterizing human lung imaging coils and enabling routine 2D- QA scans in one-minute. On longer timescales, 3D-imaging is feasible to evaluate ¹²⁹Xe coil sensitivity profiles.

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