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Abstract #4479

Assessing the Impact of Acid Aspiration with Hyperpolarized Xenon-129 Dissolved-Phase MRI

Kai Ruppert1, Hooman Hamedani1, Faraz Amzajerdian1, Luis Loza1, Yi Xin1, Ian F. Duncan1, Harilla Profka1, Sarmad Siddiqui1, Mehrdad Pourfathi1, Maurizio F. Cereda1, Stephen Kadlecek1, and Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Acid aspiration frequently occurs in critically ill patients, and can give rise to severe acute lung injury. In this study, we investigated whether hyperpolarized xenon-129 dissolved-phase MRI provides the necessary sensitivity to assess acid aspiration and associated pneumonitis in a rabbit model. We observed changes that most likely corresponded to the formation of interstitial edema as part of an inflammatory response. In particular, perilesional areas of high xenon uptake may reflect tissue at risk of secondary ventilator-induced injury.

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