Abstract #4484

Rapid hepatic glycogen synthesis in humans using dynamic 13C MR spectroscopy

Jae Mo Park^1,2,3, Stefan Stender^4,5, Craig Malloy^1,6, Jonathan Cohen⁴, Ralph DeBerardinis⁷, and Vlad Zaha^1,6

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Electrical and Computer Engineering, University of Texas at Dallas, Richardson, TX, United States, ⁴Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁵Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark, ⁶Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁷Children’s Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, United States

The development of hyperpolarized ¹³C for human patients has refocused interest on radiofrequency (RF) coil design for optimal ¹³C sensitivity. ¹³C NMR spectra were acquired from the human liver using a clamshell transmit and 8-channel paddle receive array in a 3T MRI system. Following a baseline ¹³C liver scan for 15-min, [1-¹³C]glucose was ingested and ¹³C MRS data were acquired for 1-3hrs. [1-¹³C]glucose was observed immediately after ingestion in the stomach, and evolution of [1-¹³C]glycogen was monitored with < 1min temporal resolution. ¹³C chemical shift imaging data confirmed that the glycogen signals were localized in the liver.

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