The development of hyperpolarized 13C for human patients has refocused interest on radiofrequency (RF) coil design for optimal 13C sensitivity. 13C NMR spectra were acquired from the human liver using a clamshell transmit and 8-channel paddle receive array in a 3T MRI system. Following a baseline 13C liver scan for 15-min, [1-13C]glucose was ingested and 13C MRS data were acquired for 1-3hrs. [1-13C]glucose was observed immediately after ingestion in the stomach, and evolution of [1-13C]glycogen was monitored with < 1min temporal resolution. 13C chemical shift imaging data confirmed that the glycogen signals were localized in the liver.