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Abstract #4485

Acute kidney injury in diabetic rats assessed with hyperpolarized 13C MRI

Per Mose Nielsen1, Marie Mølmer1, Rikke Nørregaard1, and Christoffer Laustsen1

1Clinical Institute, Århus N, Denmark

In this study we investigate the metabolic alterations, injury and fibrosis development when combining type 1 diabetes and IRI. We find the anaerobic metabolism is highly upregulated in the diabetic kidney, but this elevation is severely reduced in the reperfusion phase. The reduced injury repair capability of the diabetic kidney leads to high injury induction and fibrosis, which in turn reduces kidney function. Therefore special care should be taken to animals or patients experiencing this combination to avoid renal failure.

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