Abstract #4502

MR Fingerprinting and ADC Mapping for Characterization of Lesions in Transitional Zone of Prostate

Ananya Panda¹, Yun Jiang¹, Seunghee Margevicius², Wei-Ching Lo³, Mark Schluchter², Chaitra Badve^1,4, Mark Griswold^1,3,4, Lee Ponsky⁵, and Vikas Gulani^1,3,4

¹Radiology, Case Western Reserve University, Cleveland, OH, United States, ²Biostatistics, Case Western Reserve University, Cleveland, OH, United States, ³Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁴Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, ⁵Urology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States

This study presents utility of MRF derived relaxometry, and ADC mapping for differentiating transition zone prostate cancers from non-cancerous lesions. Based on targeted biopsy correlation, T₁, T₂, ADC were compared between cancer, prostatitis and normal transition zone (NTZ). Mean T₁, T₂ and ADC were significantly different between cancer and NTZ. Mean T₁ and ADC were significantly different between prostate cancer and prostatitis. While ADC had an AUC of 0.821 for differentiating cancer and prostatitis, a combination of T₁ and T₂ mapping had an AUC of 0.875. Thus MRF can add significant value to ADC mapping in characterization of TZ lesions.

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