Abstract #4503

Multicenter repeatability and reproducibility of MR Fingerprinting

Wei-Ching Lo¹, Yun Jiang², Leonardo Kayat Bittencourt^3,4, Junichi Tokuda^5,6, Ravi Seethamraju⁷, Clare Tempany-Afdhal^5,6, Ananya Panda², Katherine Wright², Mark Griswold^1,2, Nicole Seiberlich^1,2, and Vikas Gulani^1,2

¹Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Department of Radiology, University Hospitals Cleveland Medical Center at Case Western Reserve University, Cleveland, OH, United States, ³CDPI and Multi-Imagem Clinics, Rio de Janeiro, Brazil, ⁴Department of Radiology, Universidade Federal Fluminense, Niterói, RJ, Brazil, ⁵Department of Radiology, Harvard Medical School, Harvard University, Boston, MA, United States, ⁶Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States, ⁷Siemens Healthineers, Boston, MA, United States

MRF enables rapid collection of multiple tissue properties simultaneously. For clinical applications, the T₁ and T₂ values must be repeatable over time and on different MRI scanners so that any observed relaxivity difference can be assumed to be due to differences in physiology rather than scanner instability, differences in pulse sequence or map reconstruction implementations. This study evaluated multicenter repeatability and reproducibility of T₁ and T₂ estimates of MRF in the ISMRM/NIST MRI system phantom and normal prostate regions in patients. The intra-scanner variation was less than 2% for MRF T₁ and 4.7% for T₂ within the biological range.

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