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Abstract #4503

Multicenter repeatability and reproducibility of MR Fingerprinting

Wei-Ching Lo1, Yun Jiang2, Leonardo Kayat Bittencourt3,4, Junichi Tokuda5,6, Ravi Seethamraju7, Clare Tempany-Afdhal5,6, Ananya Panda2, Katherine Wright2, Mark Griswold1,2, Nicole Seiberlich1,2, and Vikas Gulani1,2

1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Department of Radiology, University Hospitals Cleveland Medical Center at Case Western Reserve University, Cleveland, OH, United States, 3CDPI and Multi-Imagem Clinics, Rio de Janeiro, Brazil, 4Department of Radiology, Universidade Federal Fluminense, Niterói, RJ, Brazil, 5Department of Radiology, Harvard Medical School, Harvard University, Boston, MA, United States, 6Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States, 7Siemens Healthineers, Boston, MA, United States

MRF enables rapid collection of multiple tissue properties simultaneously. For clinical applications, the T1 and T2 values must be repeatable over time and on different MRI scanners so that any observed relaxivity difference can be assumed to be due to differences in physiology rather than scanner instability, differences in pulse sequence or map reconstruction implementations. This study evaluated multicenter repeatability and reproducibility of T1 and T2 estimates of MRF in the ISMRM/NIST MRI system phantom and normal prostate regions in patients. The intra-scanner variation was less than 2% for MRF T1 and 4.7% for T2 within the biological range.

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