Abstract #4506

Characterization of Human Prostate Cancer Using Tissue Sodium Concentration Measured from Sodium MRI

Nolan Broeke¹, Justin Peterson¹, Adam Farag¹, Aaron Ward¹, Stephen Pautler², Joseph Chin², Glenn Bauman², Robert Bartha^1,3, and Timothy Scholl^1,3,4

¹Western University, London, ON, Canada, ²London Health Sciences Center, London, ON, Canada, ³Robarts Research Institute, London, ON, Canada, ⁴Ontario Institute for Cancer Research, Toronto, ON, Canada

Over-treatment of prostate cancer is a significant problem in men’s healthcare. Development of non-invasive imaging tools for improved identification of prostate lesions can reduce over-treatment. We have built custom sodium MRI hardware to image and quantify tissue sodium concentration (TSC) in the human prostate. Sodium and multi-parametric MR images are co-registered to Gleason-graded post-prostatectomy histology, the current gold standard for prostate cancer lesion characterization. Our data shows a statistically significant, positive correlation of TSC with Gleason score. These data suggest that TSC measured by sodium MRI, in addition to multi-parametric MRI has utility for non-invasive characterization of prostate cancer.

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