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Abstract #4506

Characterization of Human Prostate Cancer Using Tissue Sodium Concentration Measured from Sodium MRI

Nolan Broeke1, Justin Peterson1, Adam Farag1, Aaron Ward1, Stephen Pautler2, Joseph Chin2, Glenn Bauman2, Robert Bartha1,3, and Timothy Scholl1,3,4

1Western University, London, ON, Canada, 2London Health Sciences Center, London, ON, Canada, 3Robarts Research Institute, London, ON, Canada, 4Ontario Institute for Cancer Research, Toronto, ON, Canada

Over-treatment of prostate cancer is a significant problem in men’s healthcare. Development of non-invasive imaging tools for improved identification of prostate lesions can reduce over-treatment. We have built custom sodium MRI hardware to image and quantify tissue sodium concentration (TSC) in the human prostate. Sodium and multi-parametric MR images are co-registered to Gleason-graded post-prostatectomy histology, the current gold standard for prostate cancer lesion characterization. Our data shows a statistically significant, positive correlation of TSC with Gleason score. These data suggest that TSC measured by sodium MRI, in addition to multi-parametric MRI has utility for non-invasive characterization of prostate cancer.

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