Abstract #4507

Quantitative T2 in ex vivo prostate: relationship to microstructure and VERDICT MRI parameters

Colleen Bailey^1,2, Bernard Siow^3,4, Roger M Bourne⁵, Edward William Johnston⁶, Mrishta Brizmohun Appayya⁶, Hayley Pye^7,8, Susan Heavey⁷, Thomy Mertzanidou¹, Hayley Whitaker⁷, Alex Freeman⁹, Dominic Patel⁹, Greg L Shaw⁷, Ashwin Sridhar⁷, David J Hawkes¹, Shonit Punwani⁶, Daniel C Alexander¹, and Eleftheria Panagiotaki¹

¹Centre for Medical Image Computing, University College London, London, United Kingdom, ²Department of Physics, Ryerson University, Toronto, ON, Canada, ³Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, ⁴Imaging, Francis Crick Institute, London, United Kingdom, ⁵Discipline of Medical Radiation Sciences, University of Sydney, Sydney, Australia, ⁶Centre for Medical Imaging, University College London, London, United Kingdom, ⁷Division of Surgery and Interventional Science, University College London, London, United Kingdom, ⁸Department of Urology, University College London Hospitals, London, United Kingdom, ⁹Department of Research Pathology, University College London, London, United Kingdom

Quantitative T2 and VERDICT diffusion MRI data were acquired in ex vivo prostate specimens, using a patient-specific mold to allow comparison with registered prostate images. Analysis indicated differences from in vivo T2 spectra, such as a single T2 component dominating the spectrum in most regions, but with longer T2 values where there was generally more lumen space. A small component with T2 of 10-20 ms was observed in some cancerous regions. The geometric mean of the T2 spectrum was inversely correlated with the intracellular fraction parameter from VERDICT and correlated with the diffusion coefficients of the Tensor component modelling the extracellular space.

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