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Abstract #4507

Quantitative T2 in ex vivo prostate: relationship to microstructure and VERDICT MRI parameters

Colleen Bailey1,2, Bernard Siow3,4, Roger M Bourne5, Edward William Johnston6, Mrishta Brizmohun Appayya6, Hayley Pye7,8, Susan Heavey7, Thomy Mertzanidou1, Hayley Whitaker7, Alex Freeman9, Dominic Patel9, Greg L Shaw7, Ashwin Sridhar7, David J Hawkes1, Shonit Punwani6, Daniel C Alexander1, and Eleftheria Panagiotaki1

1Centre for Medical Image Computing, University College London, London, United Kingdom, 2Department of Physics, Ryerson University, Toronto, ON, Canada, 3Centre for Advanced Biomedical Imaging, University College London, London, United Kingdom, 4Imaging, Francis Crick Institute, London, United Kingdom, 5Discipline of Medical Radiation Sciences, University of Sydney, Sydney, Australia, 6Centre for Medical Imaging, University College London, London, United Kingdom, 7Division of Surgery and Interventional Science, University College London, London, United Kingdom, 8Department of Urology, University College London Hospitals, London, United Kingdom, 9Department of Research Pathology, University College London, London, United Kingdom

Quantitative T2 and VERDICT diffusion MRI data were acquired in ex vivo prostate specimens, using a patient-specific mold to allow comparison with registered prostate images. Analysis indicated differences from in vivo T2 spectra, such as a single T2 component dominating the spectrum in most regions, but with longer T2 values where there was generally more lumen space. A small component with T2 of 10-20 ms was observed in some cancerous regions. The geometric mean of the T2 spectrum was inversely correlated with the intracellular fraction parameter from VERDICT and correlated with the diffusion coefficients of the Tensor component modelling the extracellular space.

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