Abstract #4508

The diagnostic potential and repeatability of Relative Enhanced Diffusivity (RED) as a biomarker for prostate cancer

Daniel Chen Billdal¹, Mohammed R S Sunoqrot¹, Kirsten Margrete Selnæs^1,2, Peter Thomas While³, Brage Krüger-Stokke^1,3, Helena Bertilsson^4,5, Tone Frost Bathen^1,2, and Mattijs Elschot¹

¹Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, ²St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, ³Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway, ⁴Department of Cancer Research and Molecular medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, ⁵Department of Urology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

Relative Enhanced Diffusivity (RED) expresses the relative change in ADC between lower and higher b-value regimes. The purpose of this study was to investigate the diagnostic potential and repeatability of RED as a biomarker for prostate cancer (PCa).

Ten (10) healthy volunteers and 28 high-risk patients diagnosed with PCa underwent diffusion-weighted MRI. For the healthy volunteers, the repeatability of RED was good to acceptable. For the patients, RED was able to discriminate tumors from healthy tissue in the peripheral zone using either b=50 or b=400 mm/s² as the intermediate b-value (p < 0.001).

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