Abstract #4532

Brain Structural Impairment Associated with Aberrant Functional Responses to the Valsalva Maneuver in Heart Failure

Xiaopeng Song¹, Bhaswati Roy², Sadhana Singh¹, Ashish Sahib¹, Cristina Caberera-Mino², Gregg C. Fonarow³, Mary A. Woo², and Rajesh Kumar^1,4,5

¹Departments of Anesthesiology, University of California at Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, University of California at Los Angeles, Los Angeles, CA, United States, ³Division of Cardiology, University of California at Los Angeles, Los Angeles, CA, United States, ⁴Radiological Sciences, University of California at Los Angeles, Los Angeles, CA, United States, ⁵Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States

Heart failure (HF) patients show inability to regulate heart rate and blood pressure in response to autonomic challenge. Using BOLD-fMRI and DTI-MD procedures, we found that functional MRI responses during the Valsalva maneuver in cerebellum and insular are delayed or reduced in amplitude, and comparable areas showed structural injury in HF subjects. These findings show that impaired functional responses during the Valsalva maneuver have brain structural basis in HF condition.

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