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Abstract #4533

On the (non-)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson’s disease patients

Ileana Hancu1, Radhika Madhavan2, Alexandre Boutet3, Manish Ranjan3, Julia Prusik4, Davix Xu3, Suneil Kalia3, Mojgan Hodaie3, Walter Kucharczyk3, Jeffrey Ashe1, Alfonso Fasano3, Julie Pilitsis4, and Andres Lozano3

1GE Global Research Center, Niskayuna, NY, United States, 2GE Global Research Center, Bangalore, India, 3University Hospital Network, Toronto, ON, Canada, 4Albany Medical Center, Albany, NY, United States

The equivalency of brain responses in fMRI studies of Parkinson’s disease (PD) patients studied in monopolar and bipolar deep brain stimulation (DBS) configurations was assessed. Five PD patients underwent 30s/30s ON/OFF DBS fMRI scans using their clinical (monopolar) settings and an equivalent bipolar setting, in which the cathode remained unchanged, and a proximal electrode was rendered positive; the voltage was increased by 30% to compensate for the reduced efficacy of the bipolar setting. Monopolar and bipolar configurations resulted in different patterns of brain activation; blind monopolar-bipolar conversion should be avoided for purposes of understanding mechanisms of DBS action.

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