The equivalency of brain responses in fMRI studies of Parkinson’s disease (PD) patients studied in monopolar and bipolar deep brain stimulation (DBS) configurations was assessed. Five PD patients underwent 30s/30s ON/OFF DBS fMRI scans using their clinical (monopolar) settings and an equivalent bipolar setting, in which the cathode remained unchanged, and a proximal electrode was rendered positive; the voltage was increased by 30% to compensate for the reduced efficacy of the bipolar setting. Monopolar and bipolar configurations resulted in different patterns of brain activation; blind monopolar-bipolar conversion should be avoided for purposes of understanding mechanisms of DBS action.
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